Endonuclease 8-like 2 (NEIL2) Recombinant Protein | NEIL2 recombinant protein
Recombinant Human Endonuclease 8-like 2 (NEIL2)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
Uniprot Description
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Research Articles on NEIL2
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Product Notes
The NEIL2 neil2 (Catalog #AAA1363748) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-332, Full length protein. The amino acid sequence is listed below: PEGPLVRKFH HLVSPFVGQQ VVKTGGSSKK LQPASLQSLW LQDTQVHGKK LFLRFDLDEE MGPPGSSPTP EPPQKEVQKE GAADPKQVGE PSGQKTLDGS SRSAELVPQG EDDSEYLERD APAGDAGRWL RVSFGLFGSV WVNDFSRAKK ANKRGDWRDP SPRLVLHFGG GGFLAFYNCQ LSWSSSPVVT PTCDILSEKF HRGQALEALG QAQPVCYTLL DQRYFSGLGN IIKNEALYRA GIHPLSLGSV LSASRREVLV DHVVEFSTAW LQGKFQGRPQ HTQVYQKEQC PAGHQVMKEA FGPEDGLQRL TWWCPQCQPQ LSEEPEQCQF S. It is sometimes possible for the material contained within the vial of "Endonuclease 8-like 2 (NEIL2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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