Mouse nei endonuclease VIII-like 1 (E. coli) ELISA Kit | NEIL1 elisa kit
Mouse Endonuclease 8-like 1, NEIL1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NEIL1: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Belongs to the FPG family.
Protein type: Lyase; EC 4.2.99.18; DNA repair, damage; Hydrolase
Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; chromosome; nucleus
Molecular Function: single-strand selective uracil DNA N-glycosylase activity; protein C-terminus binding; hydrolase activity, hydrolyzing N-glycosyl compounds; uracil DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; zinc ion binding; hydrolase activity; DNA N-glycosylase activity; hydrolase activity, acting on glycosyl bonds; lyase activity; purine-specific mismatch base pair DNA N-glycosylase activity; DNA-3-methyladenine glycosylase III activity; nucleic acid binding; DNA binding; damaged DNA binding; catalytic activity
Biological Process: base-excision repair; nucleotide-excision repair; metabolic process; response to oxidative stress; DNA repair; response to DNA damage stimulus; negative regulation of nuclease activity
Research Articles on NEIL1
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Product Notes
The Mouse NEIL1 neil1 (Catalog #AAA9319684) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319684 ELISA Kit recognizes Mouse NEIL1. It is sometimes possible for the material contained within the vial of "nei endonuclease VIII-like 1 (E. coli), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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