Human neural precursor cell expressed, developmentally down-regulated 4-like ELISA Kit | NEDD4L elisa kit
Human E3 ubiquitin-protein ligase NEDD4-like, NEDD4L ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Uniprot Description
NEDD4L: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Interacts with UBE2E3. Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase. Interacts via its WW domains with SCNN1A, SCNN1B, SCNN1G, SCN1A, SCN2A, SCN3A, SCN5A, SCN8A, SCN9A, SCN10A and CLCN5. Interacts with SMAD2, SMAD3, SMAD6 and SMAD7. The phosphorylated form interacts with 14-3-3 proteins. Interacts with Epstein-Barr virus LMP2A. Interacts with TNK2. Interacts with WNK1. Interacts with SGK1. By androgens in prostate, and by albumin in kidney. Ubiquitously expressed, with highest levels in prostate, pancreas and kidney. Activated by NDFIP1- and NDFIP2-binding. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ligase
Chromosomal Location of Human Ortholog: 18q21.31
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; intracellular; cytosol; nucleus
Molecular Function: sodium channel inhibitor activity; protein binding; potassium channel regulator activity; sodium channel regulator activity; ubiquitin-protein ligase activity; potassium channel inhibitor activity; ligase activity
Biological Process: protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process; transcription initiation from RNA polymerase II promoter; response to metal ion; cellular sodium ion homeostasis; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; viral reproduction; negative regulation of systemic arterial blood pressure; sodium ion transport; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination; positive regulation of endocytosis; negative regulation of transcription from RNA polymerase II promoter; viral infectious cycle; excretion; response to salt stress; water homeostasis; regulation of membrane potential; transforming growth factor beta receptor signaling pathway; positive regulation of protein catabolic process; regulation of protein catabolic process; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; transmembrane transport
Research Articles on NEDD4L
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Product Notes
The Human NEDD4L nedd4l (Catalog #AAA9325942) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325942 ELISA Kit recognizes Human NEDD4L. It is sometimes possible for the material contained within the vial of "neural precursor cell expressed, developmentally down-regulated 4-like, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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