Nedd4 Family Interacting Protein 1 Recombinant Protein | NDFIP1 recombinant protein

Recombinant Human Nedd4 Family Interacting Protein 1

Cat. Num. AAA145965

• Gene Names: NDFIP1; N4WBP5
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Nedd4 Family Interacting Protein 1; Recombinant Human Nedd4 Family Interacting Protein 1; NDFIP1 Human; Nedd4 Family Interacting Protein 1 Human Recombinant; N4WBP5; NEDD4 family-interacting protein 1; Breast cancer-associated protein SGA-1M; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein; NDFIP1; NDFIP1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The NDFIP1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMALALAA LAAVEPACGS RYQQLQNEEE SGEPEQAAGD APPPYSSISA ESAAYFDYKD ESGFPKPPSY NVATTLPSYD EAERTKAEAT IPLVPGRDED FVGRDDFDDA DQLRIGNDG
• Sequence Length: 221

Related Product Information for NDFIP1 recombinant protein

Description: NDFIP1 Human Recombinant produced in E Coli is. a single polypeptide chain containing 139 amino acids (1-116) and having a molecular mass of 14.8kDa. NDFIP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Nedd4 Family Interacting Protein 1 (NDFIP1) is a part of a small group of evolutionarily conserved proteins having 3 ransmembrane domains. NDFIP1 is a possible target for ubiquitination by the Nedd4 family of proteins. NDFIP, which is a member of a family of integral Golgi membrane proteins, also modulates EGFR signaling through multiple pathways.

Product Categories/Family for NDFIP1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 13386480
• NCBI GeneID: 80762
• NCBI Accession #: NP_085048.1
• NCBI GenBank Nucleotide #: NM_030571.3
• UniProt Accession #: Q9BT67; Q658T8; Q8N2E3; Q8N2F9; B2RDB8; D3DQF0
• Molecular Weight: 16,915 Da
• NCBI Official Full Name: NEDD4 family-interacting protein 1
• NCBI Official Synonym Full Names: Nedd4 family interacting protein 1
• NCBI Official Symbol: NDFIP1
• NCBI Official Synonym Symbols: N4WBP5
• NCBI Protein Information: NEDD4 family-interacting protein 1; Nedd4 WW domain-binding protein 5; breast cancer-associated protein SGA-1M; putative MAPK-activating protein PM13; putative NF-kappa-B-activating protein 164; putative NFKB and MAPK-activating protein
• UniProt Protein Name: NEDD4 family-interacting protein 1
• Protein Family: NEDD4 family-interacting protein
• UniProt Gene Name: NDFIP1
• UniProt Synonym Gene Names: N4WBP5
• UniProt Entry Name: NFIP1_HUMAN

NCBI Description

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]

Uniprot Description

NDFIP1: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Adaptor/scaffold; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: Golgi membrane; perinuclear region of cytoplasm; extracellular region; integral to membrane; endosome membrane; cell cortex

Molecular Function: signal transducer activity; protein binding; WW domain binding

Biological Process: negative regulation of interleukin-4 production; positive regulation of I-kappaB kinase/NF-kappaB cascade; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; cellular iron ion homeostasis; regulation of lymphocyte differentiation; regulation of myeloid leukocyte differentiation; signal transduction; negative regulation of isotype switching to IgE isotypes; negative regulation of T cell proliferation; negative regulation of T-helper 2 type immune response; positive regulation of protein ubiquitination; negative regulation of inflammatory response; positive regulation of protein catabolic process; negative regulation of protein transport; regulation of isotype switching to IgG isotypes; negative regulation of transporter activity