Human nuclear receptor coactivator 4 ELISA Kit | NCOA4 elisa kit
Human Nuclear receptor coactivator 4, NCOA4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Uniprot Description
NCOA4: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Defects in NCOA4 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: nucleus
Molecular Function: androgen receptor binding; transcription coactivator activity
Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; male gonad development; response to hormone stimulus
Disease: Thyroid Carcinoma, Papillary
Research Articles on NCOA4
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Product Notes
The Human NCOA4 ncoa4 (Catalog #AAA9329141) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329141 ELISA Kit recognizes Human NCOA4. It is sometimes possible for the material contained within the vial of "nuclear receptor coactivator 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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