Thymosin-b4 Native Protein | TMSB4X native protein
Thymosin-b4
Gene Names
TMSB4X; FX; TB4X; PTMB4; TMSB4
Purity
Greater than 98.0% as determined by RP-HPLC.
Synonyms
Thymosin-b4; Thymosin beta4; Thymosin b4; Thymosin beta-4; T beta 4; Fx; TB4X; PTMB4; TMSB4; TMSB4X native protein
Purity/Purification
Greater than 98.0% as determined by RP-HPLC.
Form/Format
The protein (1 mg/ml) was lyophilized with no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
Thymosin b4 has an a.a. sequence of Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
Sequence Length
44
Solubility
It is recommended to reconstitute the lyophilized Thymosin beta-4 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Preparation and Storage
Lyophilized Thymosin b4 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution T beta 4 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Related Product Information for TMSB4X native protein
Description: Thymosin b4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide.It has a molecular weight of 4963.55 Da, and its molecular formula is: C212H350N56O78S1. Extracellular Thymosin b4 may contribute to physiological processes such as angiogenesis, wound healing, and regulation of inflammation. Thymosin b4 has an a.a. sequence of Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH.
Introduction: Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin b4, is a member of a highly conserved family of actin monomer-sequestering proteins. b-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin.
Introduction: Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin b4, is a member of a highly conserved family of actin monomer-sequestering proteins. b-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
5,053 Da
NCBI Official Full Name
thymosin beta-4
NCBI Official Synonym Full Names
thymosin beta 4, X-linked
NCBI Official Symbol
TMSB4X
NCBI Official Synonym Symbols
FX; TB4X; PTMB4; TMSB4
NCBI Protein Information
thymosin beta-4; prothymosin beta-4; t beta-4; thymosin, beta 4, X chromosome
UniProt Protein Name
Thymosin beta-4
Protein Family
UniProt Gene Name
TMSB4X
UniProt Synonym Gene Names
TB4X; THYB4; TMSB4; T beta-4
UniProt Entry Name
TYB4_HUMAN
NCBI Description
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
Uniprot Description
TMSB4X: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq21.3-q22
Cellular Component: cytoskeleton; extracellular region
Molecular Function: actin monomer binding; protein binding
Biological Process: platelet activation; platelet degranulation; sequestering of actin monomers; actin filament organization; blood coagulation
Research Articles on TMSB4X
Similar Products
Product Notes
The TMSB4X tmsb4x (Catalog #AAA142668) is a Native Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Thymosin b4 has an a.a. sequence of Ac-Ser-Asp -Lys-Pro-A sp-Met-Ala -Glu-Ile-G lu-Lys-Phe -Asp-Lys-S er-Lys-Leu -Lys-Lys-T hr-Glu-Thr -Gln-Glu-L ys-Asn-Pro -Leu-Pro-S er-Lys-Glu -Thr-Ile-G lu-Gln-Glu -Lys-Gln-A la-Gly-Glu -Ser-OH. It is sometimes possible for the material contained within the vial of "Thymosin-b4, Native Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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