Goat N-Acetyltransferase 8 Like Protein ELISA Kit | NAT8L elisa kit

Goat N-Acetyltransferase 8 Like Protein ELISA Kit

• Gene Names: NAT8L; CML3; NACED; NAT8-LIKE
• Reactivity: Goat
• Synonyms: N-Acetyltransferase 8 Like Protein; Goat N-Acetyltransferase 8 Like Protein ELISA Kit; NAT8L elisa kit

• Reactivity: Goat
• Sequence Length: 302

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 259016335
• NCBI GeneID: 339983
• UniProt Accession #: Q8N9F0
• Molecular Weight: 32,837 Da
• NCBI Official Full Name: N-acetylaspartate synthetase
• NCBI Official Synonym Full Names: N-acetyltransferase 8-like (GCN5-related, putative)
• NCBI Official Symbol: NAT8L
• NCBI Official Synonym Symbols: CML3; NACED; NAT8-LIKE
• NCBI Protein Information: N-acetylaspartate synthetase; NAA synthetase; camello-like protein 3
• UniProt Protein Name: N-acetylaspartate synthetase
• Protein Family: N-acetylaspartate synthetase
• UniProt Gene Name: NAT8L
• UniProt Synonym Gene Names: CML3; NAA synthetase
• UniProt Entry Name: NAT8L_HUMAN

NCBI Description

This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]

Uniprot Description

NAT8L: Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. Defects in NAT8L are the cause of N-acetylaspartate deficiency (NACED). A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly. Belongs to the camello family.

Protein type: EC 2.3.1.17; Acetyltransferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: mitochondrion; mitochondrial membrane; cytoplasm; integral to membrane; rough endoplasmic reticulum membrane

Molecular Function: aspartate N-acetyltransferase activity

Biological Process: positive regulation of dopamine uptake; metabolic process

Disease: N-acetylaspartate Deficiency