NAT8 Blocking Peptide | NAT8 (HGNC:18069) blocking peptide

NAT8 Antibody (Center) Blocking Peptide

• Gene Names: NAT8; GLA; CML1; CCNAT; Hcml1; ATase2; TSC501; TSC510
• Synonyms: NAT8; NAT8 Antibody (Center) Blocking Peptide; N-acetyltransferase 8; 231-; Acetyltransferase 2; ATase2; Camello-like protein 1; Cysteinyl-conjugate N-acetyltransferase; CCNAT; NAT8 (HGNC:18069) blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 227

• Cellular Location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein Endoplasmic reticulum membrane; Single-pass type II membrane protein
• Tissue Location: Preferentially expressed in liver and kidney. Also detected in brain (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NAT8 (HGNC:18069) blocking peptide

Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).

NCBI and Uniprot Product Information

• NCBI GI #: 145566894
• NCBI GeneID: 9027
• UniProt Accession #: Q9UHE5; O75839; Q6LEU4; Q96QI8; Q9UQ17
• Molecular Weight: 25,619 Da
• NCBI Official Full Name: N-acetyltransferase 8
• NCBI Official Synonym Full Names: N-acetyltransferase 8 (putative)
• NCBI Official Symbol: NAT8
• NCBI Official Synonym Symbols: GLA; CML1; CCNAT; Hcml1; ATase2; TSC501; TSC510
• NCBI Protein Information: N-acetyltransferase 8
• UniProt Protein Name: N-acetyltransferase 8
• UniProt Gene Name: NAT8
• UniProt Synonym Gene Names: ATase2; CCNAT
• UniProt Entry Name: NAT8_HUMAN

NCBI Description

This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008]

Uniprot Description

NAT8: Plays a role in regulation of gastrulation. Belongs to the camello family.

Protein type: EC 2.3.1.80; Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass; Acetyltransferase

Chromosomal Location of Human Ortholog: 2p13.2

Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment; ER-Golgi intermediate compartment membrane; integral to membrane

Molecular Function: cysteine-S-conjugate N-acetyltransferase activity; lysine N-acetyltransferase activity; protein binding

Biological Process: beta-amyloid metabolic process; cellular protein metabolic process; glutathione metabolic process; negative regulation of apoptosis; peptidyl-lysine N6-acetylation; response to drug