NAPSA recombinant protein

NAPSA, 64-420aa, Human, His tag, E Coli

Cat. Num. AAA206358

• Gene Names: NAPSA; KAP; Kdap; NAP1; NAPA; SNAPA
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: NAPSA; 64-420aa; Human; His tag; E Coli; Napsin-A; KAP; Kdap; NAP1; NAPA; SNAPA; NAPSA recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl (pH 8.0) containing 10% glycerol
• Concentration: 0.25 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSKPIFVPL SNYRDVQYFG EIGLGTPPQN FTVAFDTGSS NLWVPSRRCH FFSVPCWLHH RFDPKASSSF QANGTKFAIQ YGTGRVDGIL SEDKLTIGGI KGASVIFGEA LWEPSLVFAF AHFDGILGLG FPILSVEGVR PPMDVLVEQG LLDKPVFSFY LNRDPEEPDG GELVLGGSDP AHYIPPLTFV PVTVPAYWQI HMERVKVGPG LTLCAKGCAA ILDTGTSLIT GPTEEIRALH AAIGGIPLLA GEYIILCSEI PKLPAVSFLL GGVWFNLTAH DYVIQTTRNG VRLCLSGFQA LDVPPPAGPF WILGDVFLGT YVAVFDRGDM KSSARVGLAR ARTRGADLGW GETAQAQFPG
• Sequence Length: 420

• Applicable Applications for NAPSA recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for NAPSA recombinant protein

NAPSA, also known as Napsin-A, belongs to the peptidase A1 family and may be involved in processing of pneumocyte surfactant precursors. The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. Recombinant human NAPSA, fused to His-tag at N-terminus, was expressed in E Coli and purified by conventional chromatography.

Product Categories/Family for NAPSA recombinant protein

Proteases & Inhibitors

References

Aulakh KS, et al. (2013) Arch. Pathol. Lab. Med. 137 (8):1094-8; Chernock RD, et al. (2013) Am. J. Surg. Pathol. 37 (8):1215-22

NCBI and Uniprot Product Information

• NCBI GI #: 4758754
• NCBI GeneID: 9476
• NCBI Accession #: NP_004842
• NCBI GenBank Nucleotide #: NM_004851.2
• UniProt Accession #: O96009; Q8WWD9
• Molecular Weight: 40.9 kDa (380 aa) confirmed by MALDI-TOF
• NCBI Official Full Name: napsin-A preproprotein
• NCBI Official Synonym Full Names: napsin A aspartic peptidase
• NCBI Official Symbol: NAPSA
• NCBI Official Synonym Symbols: KAP; Kdap; NAP1; NAPA; SNAPA
• NCBI Protein Information: napsin-A
• UniProt Protein Name: Napsin-A
• Protein Family: Napsin
• UniProt Gene Name: NAPSA
• UniProt Synonym Gene Names: NAP1; NAPA; ASP4; Asp 4

NCBI Description

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

Uniprot Description

May be involved in processing of pneumocyte surfactant precursors.