BIRC1 recombinant protein

BIRC1 protein (His tag)

Cat. Num. AAA5303936

• Gene Names: NAIP; BIRC1; NLRB1; psiNAIP
• Purity: > 90% pure
• Synonyms: BIRC1; BIRC1 protein (His tag); Baculoviral IAP repeat-containing 1 protein; Baculoviral IAP repeat-containing protein 1; BIRC1 protein; FLJ18088 protein; FLJ42520 protein; FLJ58811 protein; NAIP protein; Neuronal apoptosis inhibitory protein protein; NLR family; apoptosis inhibitory protein protein; BIR domain containing 1 protein; NLRB1 protein; nucleotide-binding oligomerization domain; leucine rich repeat and BIR domain containing 1 protein; psi neuronal apoptosis inhibitory protein protein; psiNAIP protein; BIRC1 recombinant protein

• Host: Human
• Purity/Purification: > 90% pure
• Form/Format: Supplied in a Tris-based buffer containing 50% glycerol
• Sequence Length: 1403

• Protein Type: Recombinant
• Biological Significance: BIRC1 has an importantrole in apoptosis, cytokine production, and chromosome segregation.
• Expression System: E Coli
• Tag/Conjugate: His tag
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 or -80 degree C

Related Product Information for BIRC1 recombinant protein

Purified recombinant BIRC1 protein (His tag)

Product Categories/Family for BIRC1 recombinant protein

Cell Cycle & Cell Death; Conjugated Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 119393878
• NCBI GeneID: 4671
• NCBI Accession #: NP_004527.2
• NCBI GenBank Nucleotide #: NM_004536.2
• Molecular Weight: 141,329 Da
• NCBI Official Full Name: baculoviral IAP repeat-containing protein 1 isoform 1
• NCBI Official Synonym Full Names: NLR family, apoptosis inhibitory protein
• NCBI Official Symbol: NAIP
• NCBI Official Synonym Symbols: BIRC1; NLRB1; psiNAIP
• NCBI Protein Information: baculoviral IAP repeat-containing protein 1
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 1
• UniProt Gene Name: NAIP
• UniProt Synonym Gene Names: BIRC1
• UniProt Entry Name: BIRC1_HUMAN

NCBI Description

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BIRC1: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: spindle microtubule; basolateral plasma membrane; cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; ATP binding

Biological Process: nervous system development; protein ubiquitination; innate immune response; regulation of signal transduction; negative regulation of neuron apoptosis; negative regulation of caspase activity; inflammatory response; negative regulation of apoptosis