N-acetylglutamate synthase, mitochondrial (NAGS) Recombinant Protein | NAGS recombinant protein
Recombinant Human N-acetylglutamate synthase, mitochondrial (NAGS)
Gene Names
NAGS; AGAS; ARGA
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
N-acetylglutamate synthase; mitochondrial (NAGS); Recombinant Human N-acetylglutamate synthase; NAGS recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
19-534, Full length protein
Sequence
LRGRGGTGGARRLSCGARRRAARGTSPGRRLSTAWSQPQPPPEEYAGADDVSQSPVAEEPSWVPSPRPPVPHESPEPPSGRSLVQRDIQAFLNQCGASPGEARHWLTQFQTCHHSADKPFAVIEVDEEVLKCQQGVSSLAFALAFLQRMDMKPLVVLGLPAPTAPSGCLSFWEAKAQLAKSCKVLVDALRHNAAAAVPFFGGGSVLRAAEPAPHASYGGIVSVETDLLQWCLESGSIPILCPIGETAARRSVLLDSLEVTASLAKALRPTKIIFLNNTGGLRDSSHKVLSNVNLPADLDLVCNAEWVSTKERQQMRLIVDVLSRLPHHSSAVITAASTLLTELFSNKGSGTLFKNAERMLRVRSLDKLDQGRLVDLVNASFGKKLRDDYLASLRPRLHSIYVSEGYNAAAILTMEPVLGGTPYLDKFVVSSSRQGQGSGQMLWECLRRDLQTLFWRSRVTNPINPWYFKHSDGSFSNKQWIFFWFGLADIRDSYELVNHAKGLPDSFHKPASDPGS
Sequence Length
516
Species
Human
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for NAGS recombinant protein
The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
58,156 Da
NCBI Official Full Name
N-acetylglutamate synthase, mitochondrial
NCBI Official Synonym Full Names
N-acetylglutamate synthase
NCBI Official Symbol
NAGS
NCBI Official Synonym Symbols
AGAS; ARGA
NCBI Protein Information
N-acetylglutamate synthase, mitochondrial
UniProt Protein Name
N-acetylglutamate synthase, mitochondrial
Protein Family
UniProt Gene Name
NAGS
NCBI Description
The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008]
Uniprot Description
Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity.
Research Articles on NAGS
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Product Notes
The NAGS nags (Catalog #AAA1387203) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 19-534, Full length protein. The amino acid sequence is listed below: LRGRGGTGGA RRLSCGARRR AARGTSPGRR LSTAWSQPQP PPEEYAGADD VSQSPVAEEP SWVPSPRPPV PHESPEPPSG RSLVQRDIQA FLNQCGASPG EARHWLTQFQ TCHHSADKPF AVIEVDEEVL KCQQGVSSLA FALAFLQRMD MKPLVVLGLP APTAPSGCLS FWEAKAQLAK SCKVLVDALR HNAAAAVPFF GGGSVLRAAE PAPHASYGGI VSVETDLLQW CLESGSIPIL CPIGETAARR SVLLDSLEVT ASLAKALRPT KIIFLNNTGG LRDSSHKVLS NVNLPADLDL VCNAEWVSTK ERQQMRLIVD VLSRLPHHSS AVITAASTLL TELFSNKGSG TLFKNAERML RVRSLDKLDQ GRLVDLVNAS FGKKLRDDYL ASLRPRLHSI YVSEGYNAAA ILTMEPVLGG TPYLDKFVVS SSRQGQGSGQ MLWECLRRDL QTLFWRSRVT NPINPWYFKH SDGSFSNKQW IFFWFGLADI RDSYELVNHA KGLPDSFHKP ASDPGS. It is sometimes possible for the material contained within the vial of "N-acetylglutamate synthase, mitochondrial (NAGS), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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