Unconventional myosin-IXb (Myo9b) Recombinant Protein | Myo9b recombinant protein

Recombinant Mouse Unconventional myosin-IXb (Myo9b) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Unconventional myosin-IXb (Myo9b); Recombinant Mouse Unconventional myosin-IXb (Myo9b); partial; Myo9b recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,961

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Myo9b recombinant protein

This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 14548121
• NCBI GeneID: 17925
• UniProt Accession #: Q9QY06; Q9QY07; Q9QY08; Q9QY09
• Molecular Weight: 222,444 Da
• NCBI Official Full Name: Unconventional myosin-IXb
• NCBI Official Synonym Full Names: myosin IXb
• NCBI Official Symbol: Myo9b
• NCBI Protein Information: unconventional myosin-IXb
• UniProt Protein Name: Unconventional myosin-IXb
• Protein Family: Unconventional myosin
• UniProt Gene Name: Myo9b
• UniProt Synonym Gene Names: Myr5

Uniprot Description

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA.