Unconventional myosin-XV (MYO15A) Recombinant Protein | MYO15A recombinant protein

Recombinant Human Unconventional myosin-XV (MYO15A) , partial

• Gene Names: MYO15A; DFNB3; MYO15
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Unconventional myosin-XV (MYO15A); Recombinant Human Unconventional myosin-XV (MYO15A); partial; MYO15A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 797

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for MYO15A recombinant protein

This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 118402590
• NCBI GeneID: 51168
• NCBI Accession #: NP_057323.3
• NCBI GenBank Nucleotide #: NM_016239.3
• UniProt Accession #: Q9UKN7; B4DFC7
• Molecular Weight: 88,988 Da
• NCBI Official Full Name: unconventional myosin-XV
• NCBI Official Synonym Full Names: myosin XVA
• NCBI Official Symbol: MYO15A
• NCBI Official Synonym Symbols: DFNB3; MYO15
• NCBI Protein Information: unconventional myosin-XV
• UniProt Protein Name: Unconventional myosin-XV
• Protein Family: Unconventional myosin
• UniProt Gene Name: MYO15A
• UniProt Synonym Gene Names: MYO15

NCBI Description

This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles ().