Goat Mucin 4 ELISA Kit | MUC4 elisa kit

Goat Mucin 4 ELISA Kit

Cat. Num. AAA749826

• Gene Names: MUC4; ASGP; MUC-4; HSA276359
• Reactivity: Goat
• Synonyms: Mucin 4; Goat Mucin 4 ELISA Kit; MUC4 elisa kit

• Reactivity: Goat

• Preparation and Storage: Store all reagents at 2-8 degree C

Product Categories/Family for MUC4 elisa kit

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 3551823
• NCBI GeneID: 4585
• UniProt Accession #: Q99102; O95938; Q9GZM2; Q9GZV6; Q9H481; Q9H482; Q9H483; Q9H484; Q9H485; Q9H486; Q9H487; Q9H4D6
• Molecular Weight: 231,518 Da
• NCBI Official Full Name: mucin 4
• NCBI Official Synonym Full Names: mucin 4, cell surface associated
• NCBI Official Symbol: MUC4
• NCBI Official Synonym Symbols: ASGP; MUC-4; HSA276359
• NCBI Protein Information: mucin-4; testis mucin; tracheobronchial mucin; ascites sialoglycoprotein; mucin 4, tracheobronchial; pancreatic adenocarcinoma mucin
• UniProt Protein Name: Mucin-4
• Protein Family: Mucin
• UniProt Gene Name: MUC4
• UniProt Synonym Gene Names: MUC-4; ASGP; ASGP-1; ASGP-2
• UniProt Entry Name: MUC4_HUMAN

NCBI Description

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]

Uniprot Description

MUC4: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. 14 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: proteinaceous extracellular matrix; extracellular space; membrane; Golgi lumen; integral to plasma membrane; vesicle

Molecular Function: ErbB-2 class receptor binding; extracellular matrix constituent, lubricant activity

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; maintenance of gastrointestinal epithelium; cell-matrix adhesion; post-translational protein modification