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Mucin 2 (MUC2) Recombinant Protein | MUC2 recombinant protein
Recombinant Mucin 2 (MUC2)
MGHHHHHHSGSEF-VPCCFWS DWINKYHPTK ENGGDRETFT HVCSAPEDIE CRAATDPKLS WEELGQKVQC NVSTGLICNN EDQYGIGEFE LCYDYEIRVN CCYPMEYCTP STISPTTSTT TLSTTPPTSS PTTLPTSSPV TSSATLPTTS SITSTISPTT SP
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
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NCBI and Uniprot Product Information
Uniprot Description
Function: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Ref.6 Ref.7 UniProtKB Q02817
Subunit structure: Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization
By similarity. Interacts with FCGBP. Interacts with AGR2; disulfide-linked
By similarity. Ref.7 UniProtKB Q02817
Subcellular location: Secreted. Note: In the intestine, secreted into the inner and outer mucus layers. Ref.6 Ref.7
Tissue specificity: Highly expressed in goblet cells of the colon with lower levels in the small intestine and no expression in the stomach (at protein level). Ref.1 Ref.2
Post-translational modification: O-glycosylated. Ref.2May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria. Ref.6May undergo autocatalytic cleavage in vivo triggered by the low pH of the late secretory pathway
By similarity. UniProtKB Q02817
Disruption phenotype: Aberrant intestinal crypt morphology and altered cell maturation and migration. Frequent development of adenomas in the small intestine which progress to invasive adenocarcinomas, as well as rectal tumors. Absence of inner and outer mucus layers in the colon so that bacteria are in direct contact with the colon epithelium and enter into the cells and crypts in contrast to wild-type animals which are devoid of bacteria in the inner mucus layer. Ref.5 Ref.6
Sequence similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 TIL (trypsin inhibitory-like) domain.Contains 2 VWFC domains.Contains 4 VWFD domains.
Sequence caution: The sequence AAH30862.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on MUC2
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Product Notes
The MUC2 muc2 (Catalog #AAA2010239) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Mucin 2 (MUC2) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the MUC2 muc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF-VPCCFW S DWINKYHPTK ENGGDRETFT HVCSAPEDIE CRAATDPKLS WEELGQKVQC NVSTGLICNN EDQYGIGEFE LCYDYEIRVN CCYPMEYCTP STISPTTSTT TLSTTPPTSS PTTLPTSSPV TSSATLPTTS SITSTISPTT SP. It is sometimes possible for the material contained within the vial of "Mucin 2 (MUC2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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