CA125/MUC16 Biotinylated Recombinant Protein | CA125/MUC16 recombinant protein

Recombinant Human CA125/MUC16 (C-Fc-Avi) Biotinylated

Cat. Num. AAA2569093

• Gene Names: MUC16; CA125
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: CA125/MUC16 Biotinylated; Recombinant Human CA125/MUC16 (C-Fc-Avi) Biotinylated; CA125 ovarian cancer antigen; CA125; CA-125; CA125MUC-16; FLJ14303; MUC16; mucin 16; cell surface associated; mucin-16; CA125/MUC16 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH7.5.
• Sequence: Gly12660-Met12923

• Species: Human
• Tag: C-Fc-Avi
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Biotinylated Recombinant Human Mucin-16 is produced by our Mammalian expression system and the target gene encoding Gly12660-Met12923 is expressed with a Fc, Avi tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for CA125/MUC16 recombinant protein

MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC16-expressing tumors adhere to NK cells, down-regulate CD16 and suppress NK response, which may promote immune evasion. MUC16 is also cyclically expressed in the endometrium and may contribute to immune privilege during pregnancy. In the eye, MUC16 and other mucins protect the cornea and keep it hydrated. It is altered on the conjunctival epithelium of patients with non-Sjogren dry eye syndrome.

Product Categories/Family for CA125/MUC16 recombinant protein

Signal Transduction; Tags & Cell Markers; Cancer; immunology

NCBI and Uniprot Product Information

• NCBI GI #: 83367077
• NCBI GeneID: 94025
• NCBI Accession #: NP_078966.2
• NCBI GenBank Nucleotide #: NM_024690.2
• UniProt Accession #: Q8WXI7; Q6ZQW5; Q96RK2
• Molecular Weight: 2,353,428 Da
• NCBI Official Full Name: mucin-16
• NCBI Official Synonym Full Names: mucin 16, cell surface associated
• NCBI Official Symbol: MUC16
• NCBI Official Synonym Symbols: CA125
• NCBI Protein Information: mucin-16; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125
• UniProt Protein Name: Mucin-16
• UniProt Gene Name: MUC16
• UniProt Synonym Gene Names: CA125; MUC-16; CA-125
• UniProt Entry Name: MUC16_HUMAN

Uniprot Description

MUC16: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular space; extrinsic to membrane; Golgi lumen; integral to membrane; plasma membrane; vesicle

Molecular Function: protein binding

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; cell adhesion; post-translational protein modification