MT-ND5 / NADH-Ubiquinone Oxidoreductase Chain 5 Recombinant Protein | MT-ND5 recombinant protein

Human MT-ND5 / NADH-Ubiquinone Oxidoreductase Chain 5 Recombinant Protein

• Gene Names: MT-ND5; MTND5; ND5
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: MT-ND5 / NADH-Ubiquinone Oxidoreductase Chain 5; Human MT-ND5 / NADH-Ubiquinone Oxidoreductase Chain 5 Recombinant Protein; NADH-ubiquinone oxidoreductase chain 5; NADH dehydrogenase subunit 5; MTND5; NADH5; ND5; MT-ND5 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 603

• Applicable Applications for MT-ND5 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Entry Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 251831117
• NCBI GeneID: 4540
• NCBI Accession #: YP_003024036.1
• NCBI GenBank Nucleotide #: YP_003024036.1
• UniProt Accession #: P03915
• NCBI Official Full Name: NADH dehydrogenase subunit 5 (mitochondrion)
• NCBI Official Synonym Full Names: mitochondrially encoded NADH dehydrogenase 5
• NCBI Official Symbol: MT-ND5
• NCBI Official Synonym Symbols: MTND5; ND5
• NCBI Protein Information: NADH dehydrogenase, subunit 5 (complex I)
• UniProt Protein Name: NADH-ubiquinone oxidoreductase chain 5
• UniProt Gene Name: MT-ND5
• UniProt Synonym Gene Names: MTND5; NADH5; ND5
• UniProt Entry Name: NU5M_HUMAN

Uniprot Description

MT-ND5: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND5 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND5 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Defects in MT-ND5 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Defects in MT-ND5 are a cause of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS). MELAS is a genetically heterogenious disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. Belongs to the complex I subunit 5 family.

Protein type: Membrane protein, integral; EC 1.6.5.3; Oxidoreductase; Mitochondrial; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: -

Disease: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes; Leber Optic Atrophy