Mouse membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) ELISA Kit | MS4A2 elisa kit
Mouse High affinity immunoglobulin epsilon receptor subunit beta, MS4A2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Description
FcER1B: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Belongs to the MS4A family.
Protein type: Membrane protein, multi-pass; Receptor, misc.; Membrane protein, integral
Cellular Component: membrane; integral to plasma membrane; Fc-epsilon receptor I complex; integral to membrane; endosome; lipid raft; external side of plasma membrane
Molecular Function: phosphoprotein binding; SH2 domain binding; IgE binding; protein kinase binding; IgE receptor activity
Biological Process: cell surface receptor linked signal transduction; phospholipase C activation; protein kinase C activation; positive regulation of mast cell degranulation; immune response; inflammatory response; signal transduction; cytokine secretion; regulation of release of sequestered calcium ion into cytosol
Research Articles on MS4A2
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Product Notes
The Mouse MS4A2 ms4a2 (Catalog #AAA9320760) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320760 ELISA Kit recognizes Mouse MS4A2. It is sometimes possible for the material contained within the vial of "membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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