WB (Western Blot)
(Western blot analysis of anti-JHDM1a/FBXL11 Antibody (C-term) (AAA288022) pre-incubated with(right lane) and without(left lane) blocking peptide in Jurkat cell line lysate. JHDM1a(arrow) was detected using the purified Pab.)
Rabbit JHDM1a/FBXL11 Polyclonal Antibody | anti-KDM2A antibody
JHDM1a/FBXL11 Antibody (C-term)
Gene Names
KDM2A; FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
Reactivity
Human (Predicted Reactivity: Mouse)
Applications
ELISA, Western Blot
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
JHDM1a/FBXL11, Antibody; JHDM1a/FBXL11 Antibody (C-term); Lysine-specific demethylase 2A; CXXC-type zinc finger protein 8; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; JmjC domain-containing histone demethylation protein 1A; [Histone-H3]-lysine-36 demethylase 1A; KDM2A; CXXC8; FBL7; FBXL11; JHDM1A; KIAA1004; anti-KDM2A antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This JHDM1a/FBXL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 867-896 amino acids from the C-terminal region of human JHDM1a/FBXL11.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Sequence Positions
867-896
Sequence Length
723
Applicable Applications for anti-KDM2A antibody
ELISA, WB (Western Blot)
Clone Names
RB14305
Function
Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
Cellular Location
Nucleus, nucleoplasm Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2
Tissue Location
Widely expressed, with highest levels in brain, testis and ovary, followed by lung
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(Western blot analysis of anti-JHDM1a/FBXL11 Antibody (C-term) (AAA288022) pre-incubated with(right lane) and without(left lane) blocking peptide in Jurkat cell line lysate. JHDM1a(arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of anti-JHDM1a/FBXL11 Antibody (C-term) (AAA288022) pre-incubated with(right lane) and without(left lane) blocking peptide in Jurkat cell line lysate. JHDM1a(arrow) was detected using the purified Pab.)
Related Product Information for anti-KDM2A antibody
JHDM1a/FBXL11 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. JHDM1a/FBXL11 belongs to the Fbls class and, in addition to an F-box, contains at least 6 highly degenerated leucine-rich repeats.
References
Tsukada,Y.,Nature 439 (7078), 811-816 (2006)
Andersen,J.S.,Nature 433 (7021), 77-83 (2005)
Andersen,J.S.,Nature 433 (7021), 77-83 (2005)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
132793
NCBI Official Full Name
lysine-specific demethylase 2A isoform b
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 2A
NCBI Official Symbol
KDM2A
NCBI Official Synonym Symbols
FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
NCBI Protein Information
lysine-specific demethylase 2A
UniProt Protein Name
Lysine-specific demethylase 2A
UniProt Gene Name
KDM2A
UniProt Synonym Gene Names
CXXC8; FBL7; FBXL11; JHDM1A; KIAA1004
UniProt Entry Name
KDM2A_HUMAN
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Product Notes
The KDM2A kdm2a (Catalog #AAA288022) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 867-896. The JHDM1a/FBXL11 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's JHDM1a/FBXL11 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the KDM2A kdm2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JHDM1a/FBXL11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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