IL-4 recombinant antibody
Anti-IL-4 [11B11]
Reactivity
Mouse
Applications
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry
Purity
Protein A Affinity Purified
Synonyms
IL-4; Anti-IL-4 [11B11]; Il4; Il-4; Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IL-4 recombinant antibody
Reactivity
Mouse
Isotype
Rabbit IgG, kappa
Clone Number
11B11
Specificity
Binds to a core functional region of murine IL-4, which prevents this cytokine from interacting with its cognate receptor (Yao et al., 2006 PMID: 16361318).
Purity/Purification
Protein A Affinity Purified
Sequence Length
133
Applicable Applications for IL-4 recombinant antibody
ELISA (EIA), Flow Cytometry (FC/FACS), In Vivo, Immunohistochemistry (IHC)
Buffer Composition
PBS only with 0.02% Proclin 300.
Immunogen
BSF-1 / IL-4 purified from serum-free supernatants of cultured EL-4 cells (a C57BL/6 thymoma) induced with 4beta-phorbol 12beta-myristate 12a-acetate for 48h.
Chimeric Use Statement
This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Related Product Information for IL-4 recombinant antibody
Recombinant monoclonal antibody to IL-4. Manufactured using a Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 11B11. This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Product Categories/Family for IL-4 recombinant antibody
References
Ohara J, Paul WE. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature. 1985 May 23-29; 315(6017):333-6. PMID:2582266
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
15,023 Da
NCBI Official Full Name
interleukin-4
NCBI Official Symbol
IL4
NCBI Protein Information
interleukin-4
UniProt Protein Name
Interleukin-4
UniProt Gene Name
IL4
UniProt Synonym Gene Names
IL-4; BSF-1
UniProt Entry Name
IL4_PIG
Uniprot Description
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
Research Articles on IL-4
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Product Notes
The IL-4 il4 (Catalog #AAA488131) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-IL-4 [11B11] reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IL-4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Flow Cytometry (FC/FACS), In Vivo, Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the IL-4 il4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-4, Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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