Immunohistochemistry (IHC)
((0.5ug/ml) staining of Mouse (A) and Rat (B) Spleen lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.)
anti-Mouse, Rat Pecam1/CD31 Antibody | anti-Pecam1 antibody
Goat anti-Pecam1/CD31 (mouse) Antibody
WB: Approx 80-85kDa band observed in Mouse and Rat Spleen lysates. Recommended concentration: 0.3-1ug/ml. Primary incubation 1 hour.at room temperature.
Immunohistochemistry (IHC)
((0.5ug/ml) staining of Mouse (A) and Rat (B) Spleen lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.)
Immunohistochemistry (IHC)
((0.5ug/ml) staining of Mouse (A) and Rat (B) Spleen lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.)
NCBI and Uniprot Product Information
Uniprot Description
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (). Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (). Modulates bradykinin receptor BDKRB2 activation (). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (). Induces susceptibility to atherosclerosis (PubMed:19048083).
Research Articles on Pecam1
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Product Notes
The Pecam1 pecam1 (Catalog #AAA423790) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Pecam1/CD31 (mouse) Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Pecam1/CD31 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Pep-ELISA: antibody detection limit dilution 1:128000. WB: Approx 80-85kDa band observed in Mouse and Rat Spleen lysates. Recommended concentration: 0.3-1ug/ml. Primary incubation 1 hour.at room temperature. Researchers should empirically determine the suitability of the Pecam1 pecam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pecam1/CD31, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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