M-CSF/CSF1 protein

M-CSF/CSF1

Cat. Num. AAA8532925

• Gene Names: CSF1; MCSF; CSF-1
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: M-CSF/CSF1; Macrophage colony-stimulating factor 1; CSF-1; MCSF; Csf1; Csfm; M-CSF/CSF1 protein

• Host: Mouse
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized
• Sequence Length: 554

• Expression System: Human Cells
• Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.; It is not recommended to reconstitute to a concentration less than 100 mug/ml.; Dissolve the lyophilized protein in ddH2O.; Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
• Preparation and Storage: Lyophilized protein should be stored at <-20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at <-20 degree C for 3 months.

Related Product Information for M-CSF/CSF1 protein

Background: Macrophage colony-stimulating factor 1(M-csf)is a single-pass type I membrane protein. It is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor, M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy.
Description: Recombinant Mouse Macrophage colony-stimulating factor 1 is produced by our Mammalian expression system and the target gene encoding Lys33-Glu262 is expressed.

NCBI and Uniprot Product Information

• NCBI GI #: 27262667
• NCBI GeneID: 1435
• NCBI Accession #: NP_757351.1
• NCBI GenBank Nucleotide #: NM_172212.2
• UniProt Accession #: P09603; Q13130; Q14086; Q14806; Q5VVF3; Q5VVF4; Q9UQR8; A8K6J5
• Molecular Weight: 29,215 Da
• NCBI Official Full Name: macrophage colony-stimulating factor 1 isoform a
• NCBI Official Synonym Full Names: colony stimulating factor 1
• NCBI Official Symbol: CSF1
• NCBI Official Synonym Symbols: MCSF; CSF-1
• NCBI Protein Information: macrophage colony-stimulating factor 1
• UniProt Protein Name: Macrophage colony-stimulating factor 1
• UniProt Gene Name: CSF1
• UniProt Synonym Gene Names: CSF-1; M-CSF; MCSF

NCBI Description

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Uniprot Description

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.