Apotransferrin Protein | TF protein

Apotransferrin, Mouse Plasma

Cat. Num. AAA844036

• Gene Names: Trf; HP; Tf; Tfn; hpx; Cd176; AI266983
• Applications: SDS-Page
• Purity: >=98%
• Synonyms: Apotransferrin; Mouse Plasma; Transferrin; TF; DKFZp781D0156; PRO1557; PRO2086; TF protein

• Host: Mouse Plasma
• Purity/Purification: >=98%
• Form/Format: Lyophilized from 20 mM Na phosphate, pH 7.4 and 150 mM NaCI.; Appearance: Lyophilized
• Sequence Length: 697

• Applicable Applications for TF protein: SDS-PAGE
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for TF protein

Background: Transferrin is a monomeric glycoprotein found in plasma at an average concentration of 250 mg/100ml. The specific iron-binding protein in plasma, it has a role in the transportation and distribution of iron among the body organs, in iron metabolism and in prevention of iron loss via the kidney. Stored in bone marrow as TF-bound iron, it also possesses bacteriostatic and fungistatic activity. Clinically, decreases in transferrin are observed in congenital disorders, newborns, inflammatory diseases, hypo-proteinemias and nephritic syndrome; increases are found in pregnancy, iron-deficiency anemias and inoculation hepatitis. Transferrin is required by all types of cells in cultures for maximal growth. It is, therefore, an important factor used in defined culture media.

Product Categories/Family for TF protein

Proteins and Enzymes; Native Proteins Proteins and Enzymes; Proteins and Enzymes (A-Z) Proteins and Enzymes; Other Proteins & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 20330802
• NCBI GeneID: 22041
• NCBI Accession #: NP_598738.1
• NCBI GenBank Nucleotide #: NM_133977.2
• UniProt Accession #: Q921I1; O35421; Q3UBW7; Q58E69; Q61803; Q62357; Q62358; Q62359; Q63915; Q64515; Q8VII5; Q922C0
• Molecular Weight: 80.0 kDa
• NCBI Official Full Name: serotransferrin
• NCBI Official Synonym Full Names: transferrin
• NCBI Official Symbol: Trf
• NCBI Official Synonym Symbols: HP; Tf; Tfn; hpx; Cd176; AI266983
• NCBI Protein Information: serotransferrin
• UniProt Protein Name: Serotransferrin
• UniProt Gene Name: Tf
• UniProt Synonym Gene Names: Trf; Transferrin
• UniProt Entry Name: TRFE_MOUSE

Uniprot Description

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; basement membrane; vesicle; endosome

Molecular Function: protein binding; ferric iron binding; metal ion binding; ferric iron transmembrane transporter activity

Biological Process: positive regulation of myelination; iron ion homeostasis; transport; positive regulation of transcription, DNA-dependent; actin filament organization; positive regulation of bone resorption; ion transport; osteoclast differentiation; ferric iron transport; iron ion transport; activation of JNK activity; positive regulation of phosphorylation