PAI-1 native protein

Mouse PAI-1 genetically deficient lung

Cat. Num. AAA135975

• Gene Names: Serpine1; PAI1; PAI-1; Planh1
• Synonyms: PAI-1; Mouse PAI-1 genetically deficient lung; PAI-1 native protein

• Host: Mouse
• Form/Format: Frozen tissue
• Sequence Length: 402

• Source Info: PAI-1 knockout mouse
• Preparation and Storage: Recommended Storage: At -70 degree C; Minimum Shelf Life: 3 years from delivery; Shipping Condition: Dry ice

Related Product Information for PAI-1 native protein

This organ is an ideal negative control for western blotting, immunoprecipitation, immunohistochemistry and other experiments involving PAI-1. Collected and flash frozen from homozygous PAI-1 knockout mice of strain B6.129S2-Serpine1 tm1Mlg /J. Each mouse lung consists of 5 lobes. The targeted PAI-1 knockout mutation was made on the C57BL/6J background strain. Mice homozygous for this mutation develop normally and are viable and fertile. Compared to wild type mice, pulmonary clot lysis is increased in the heterozygote and further increased in the homozygote. Endotoxin induced venous thrombosis is decreased compared to wild type mice. Thus, disruption of the Serpine1 gene induces a mild hyperfibrinolytic state. Hemostasis is normal in homozygous mutants.

Product Categories/Family for PAI-1 native protein

PAI-1 KNOCKOUT MOUSE PLASMA AND ORGANS

NCBI and Uniprot Product Information

• NCBI GI #: 129577
• NCBI GeneID: 18787
• UniProt Accession #: P22777
• Molecular Weight: 45,170 Da
• NCBI Official Full Name: Plasminogen activator inhibitor 1
• NCBI Official Synonym Full Names: serine (or cysteine) peptidase inhibitor, clade E, member 1
• NCBI Official Symbol: Serpine1
• NCBI Official Synonym Symbols: PAI1; PAI-1; Planh1
• NCBI Protein Information: plasminogen activator inhibitor 1; PAI; serpin E1; plasminogen activator inhibitor, type I; endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
• UniProt Protein Name: Plasminogen activator inhibitor 1
• UniProt Gene Name: Serpine1
• UniProt Synonym Gene Names: Mr1; Pai1; Planh1; PAI; PAI-1
• UniProt Entry Name: PAI1_MOUSE

Uniprot Description

SERPINE1: a secreted protein that acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protease binding; protease inhibitor activity; receptor binding

Biological Process: positive regulation of keratinocyte migration; positive regulation of blood coagulation; wound healing; negative regulation of peptidase activity; positive regulation of coagulation; negative regulation of smooth muscle cell migration; defense response to Gram-negative bacterium; regulation of angiogenesis; positive regulation of receptor-mediated endocytosis; regulation of cell proliferation; positive regulation of interleukin-8 production; positive regulation of angiogenesis; positive regulation of fibroblast proliferation; negative regulation of fibrinolysis; regulation of receptor activity; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; female gonad development; positive regulation of inflammatory response