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Immunohistochemisry (IHC)

Mouse anti-Human Placental Alkaline Phosphatase Antibody | anti-ALPP antibody

Anti-Human Placental Alkaline Phosphatase Antibody Purified

Gene Names
ALPP; ALP; PALP; PLAP; PLAP-1
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Synonyms
Placental Alkaline Phosphatase; Anti-Human Placental Alkaline Phosphatase Antibody Purified; anti-ALPP antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Isotype
IgG2a
Clone Number
4AH7E8
Form/Format
Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide
Sequence Length
530
Applicable Applications for anti-ALPP antibody
ELISA (EIA), Immunohistochemistry (IHC)
Preparation and Storage
Store at 4 degree C. DO NOT FREEZE. LIGHT SENSITIVE MATERIAL.

Immunohistochemisry (IHC)

Immunohistochemisry (IHC)

Immunohistochemisry (IHC)

(Immunohistochemistry on formalin-fixed paraffin embedded human placenta using 5 ug/mL Mouse IgG2a Isotype Control (cat. 14-4724) (left) or 5 ug/mL Anti-Human Placental Alkaline Phosphatase Purified (right) followed by biotinylated Anti-Mouse IgG, and DAB visualization. Nuclei are counterstained with hematoxylin.)

Immunohistochemisry (IHC) (Immunohistochemistry on formalin-fixed paraffin embedded human placenta using 5 ug/mL Mouse IgG2a Isotype Control (cat. 14-4724) (left) or 5 ug/mL Anti-Human Placental Alkaline Phosphatase Purified (right) followed by biotinylated Anti-Mouse IgG, and DAB visualization. Nuclei are counterstained with hematoxylin.)
Related Product Information for anti-ALPP antibody
The monoclonal antibody 4AH7E8 recognizes human Placental Alkaline Phosphatase (PLAP), a 130 (or 130 with 65 kDa) enzyme expressed by placental syncytiotrophoblastoid cells. This enzyme has slightly different enzyme kinetics from other phosphatases. PLAP can be found anchored to the plasma membrane in addition to the cytoplasm. Expression is found in several germ line cancers; ovarian and testicular. Expression is also present in human embryonic stem cells and bone marrow-derived mesenchymal stromal cells.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
250
Molecular Weight
57,954 Da
NCBI Official Full Name
placental alkaline phosphatase
NCBI Official Synonym Full Names
alkaline phosphatase, placental
NCBI Official Symbol
ALPP
NCBI Official Synonym Symbols
ALP; PALP; PLAP; PLAP-1
NCBI Protein Information
alkaline phosphatase, placental type
UniProt Protein Name
Alkaline phosphatase, placental type
Protein Family
UniProt Gene Name
ALPP
UniProt Synonym Gene Names
PLAP; PLAP-1

NCBI Description

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

Uniprot Description

MiscellaneousIn most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

Research Articles on ALPP

Similar Products

Product Notes

The ALPP alpp (Catalog #AAA8510539) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human Placental Alkaline Phosphatase Antibody Purified reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Placental Alkaline Phosphatase can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the ALPP alpp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Placental Alkaline Phosphatase, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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