Mouse Uromodulin (UMOD) ELISA Kit | UMOD elisa kit

Mouse Uromodulin (UMOD) ELISA Kit

Cat. Num. AAA450153

• Gene Names: Umod; THP; Urehd1; urehr4
• Reactivity: Mouse
• Synonyms: Uromodulin (UMOD); Mouse Uromodulin (UMOD) ELISA Kit; THP; Uromucoid; Tamm-Horsfall Glycoprotein; Tamm-Horsfall urinary glycoprotein; UMOD elisa kit

• Reactivity: Mouse
• Sequence Length: 642

• Samples: Serum, plasma, urine and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 3.125-200ng/mL
• Sensitivity: 1.14ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 519666773
• NCBI GeneID: 22242
• NCBI Accession #: NP_001265534.1
• NCBI GenBank Nucleotide #: NM_001278605.1
• UniProt Accession #: Q91X17; Q3TN64; Q3TP60; Q62285
• Molecular Weight: 70,845 Da
• NCBI Official Full Name: uromodulin preproprotein
• NCBI Official Synonym Full Names: uromodulin
• NCBI Official Symbol: Umod
• NCBI Official Synonym Symbols: THP; Urehd1; urehr4
• NCBI Protein Information: uromodulin
• UniProt Protein Name: Uromodulin
• Protein Family: Uromodulin
• UniProt Gene Name: Umod
• UniProt Synonym Gene Names: THP

NCBI Description

This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.