Mouse SS-B / La Antibody ELISA Kit | SS-B elisa kit

Mouse SS-B / La Antibody ELISA Kit

Cat. Num. AAA262423

• Gene Names: SSB; La; LARP3; La/SSB
• Reactivity: Mouse
• Synonyms: SS-B / La Antibody; Mouse SS-B / La Antibody ELISA Kit; SS-B elisa kit

• Reactivity: Mouse
• Specificity: No cross-reaction with other factors.
• Sequence Length: 64

• Samples: Mouse serum, plasma or cell culture supernatant
• Assay Type: Quantitative Sandwich
• Detection Range: 20 ng/ml-0.312 ng/ml
• Sensitivity: Up to 0.06 ng/ml
• Intra-assay Precision: <= 8%
• Inter-assay Precision: <= 12%
• Preparation and Storage: Store all reagents at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for SS-B elisa kit

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antigen is Mouse SS-B/La Ab antigen.Samples and antigen are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

NCBI and Uniprot Product Information

• NCBI GI #: 338497
• NCBI GeneID: 6741
• Molecular Weight: 46,837 Da
• NCBI Official Full Name: SS-B/La protein, partial
• NCBI Official Synonym Full Names: Sjogren syndrome antigen B (autoantigen La)
• NCBI Official Symbol: SSB
• NCBI Official Synonym Symbols: La; LARP3; La/SSB
• NCBI Protein Information: lupus La protein; SS-B; autoantigen La; la autoantigen; SS-B/La protein; lupus La antigen; sjoegren syndrome type B antigen; La ribonucleoprotein domain family, member 3
• UniProt Protein Name: Lupus La protein
• UniProt Gene Name: SSB
• UniProt Synonym Gene Names: SS-B
• UniProt Entry Name: LA_HUMAN

NCBI Description

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

Uniprot Description

SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; nucleotide binding; tRNA binding

Biological Process: RNA processing; histone mRNA metabolic process; tRNA modification