Mouse spen homolog, transcriptional regulator (Drosophila) ELISA Kit | SPEN elisa kit
Mouse Msx2-interacting protein, SPEN ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SHARP: May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. Belongs to the RRM Spen family.
Protein type: Spliceosome; RNA-binding; Nuclear receptor co-regulator; Transcription factor
Cellular Component: nucleoplasm; transcriptional repressor complex; nucleus
Molecular Function: protein binding; nucleic acid binding; DNA binding; RNA binding; nucleotide binding; transcription corepressor activity; transcription factor activity; single-stranded DNA binding
Biological Process: transcription from RNA polymerase II promoter; positive regulation of neurogenesis; Notch signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on SPEN
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Product Notes
The Mouse SPEN spen (Catalog #AAA9317121) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317121 ELISA Kit recognizes Mouse SPEN. It is sometimes possible for the material contained within the vial of "spen homolog, transcriptional regulator (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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