Mouse RANTES ELISA Kit | RANTES elisa kit

RANTES (Murine) OmniKine ELISA Kit

Cat. Num. AAA9501924

• Gene Names: Ccl5; SISd; Scya5; RANTES; TCP228; MuRantes
• Reactivity: Mouse
• Synonyms: RANTES; RANTES (Murine) OmniKine ELISA Kit; C-C motif chemokine 5; MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES; Scya5; RANTES elisa kit

• Reactivity: Mouse
• Specificity: The OmniKine Murine RANTES ELISA is capable of recognizing both recombinant and naturally produced Murine RANTES proteins. The antigens listed below were tested at 50 ng/ml and exhibited 100% cross reactivity.; Rat: RANTES; The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: MEC, RANTES, TECK; Murine: C-10, Eotaxin, JE, MCP-2, MCP-3, MCP-5, MEC, MIP-1alpha, MIP-1beta, MIP-1gamma, MIP-2, MIP-3alpha; Rat: MCP-1, MIP-1alpha, MIP-1beta
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 91

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 16-2000 pg/ml
• Sensitivity: 16-2000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Murine RANTES ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Murine RANTES proteins within the range of 16-2000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 164698428
• NCBI GeneID: 20304
• NCBI Accession #: NP_038681.2
• NCBI GenBank Nucleotide #: NM_013653.3
• UniProt Accession #: P30882
• Molecular Weight: 10,071 Da
• NCBI Official Full Name: C-C motif chemokine 5
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 5
• NCBI Official Symbol: Ccl5
• NCBI Official Synonym Symbols: SISd; Scya5; RANTES; TCP228; MuRantes
• NCBI Protein Information: C-C motif chemokine 5
• UniProt Protein Name: C-C motif chemokine 5
• UniProt Gene Name: Ccl5
• UniProt Synonym Gene Names: Scya5

Uniprot Description

CCL5: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. By mitogens. T-cell and macrophage specific. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Cell adhesion; Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11 C|11 50.66 cM

Cellular Component: cytoplasm; extracellular region; extracellular space

Molecular Function: CCR1 chemokine receptor binding; CCR4 chemokine receptor binding; CCR5 chemokine receptor binding; chemoattractant activity; chemokine activity; chemokine receptor antagonist activity; chemokine receptor binding; cytokine activity; heparin binding; phosphoinositide phospholipase C activity; phospholipase activator activity; protein homodimerization activity; protein kinase activity; protein self-association; receptor signaling protein tyrosine kinase activator activity

Biological Process: calcium ion transport; cell-cell signaling; cellular calcium ion homeostasis; cellular protein complex assembly; chemotaxis; eosinophil chemotaxis; exocytosis; G-protein coupled receptor signaling pathway; immune response; inflammatory response; leukocyte adhesion; lipopolysaccharide-mediated signaling pathway; lymphocyte chemotaxis; MAPK cascade; negative regulation of G-protein coupled receptor protein signaling pathway; negative regulation of viral genome replication; neutrophil activation; neutrophil chemotaxis; phospholipase D activation; positive regulation of angiogenesis; positive regulation of calcium ion transport; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of cellular biosynthetic process; positive regulation of defense response to virus by host; positive regulation of epithelial cell proliferation; positive regulation of fever; positive regulation of GTPase activity; positive regulation of homotypic cell-cell adhesion; positive regulation of neuron differentiation; positive regulation of osteoclast differentiation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; protein kinase B signaling; protein tetramerization; pseudopodium formation; regulation of insulin secretion; regulation of T cell activation; response to cytokine; response to toxin; response to virus