Mouse Protein C (PROC) ELISA Kit | PROC elisa kit

Mouse Protein C (PROC) ELISA Kit

Cat. Num. AAA455500

• Gene Names: Proc; PC
• Reactivity: Mouse
• Synonyms: Protein C (PROC); Mouse Protein C (PROC) ELISA Kit; PRO-C; VKDPC; PC; Vitamin K Dependent Protein C; Inactivator Of Coagulation Factors Va And VIIIa; Autoprothrombin IIA; Blood coagulation factor XIV; Activation peptide; PROC elisa kit

• Reactivity: Mouse
• Sequence Length: 460

• Samples: Plasma.
• Assay Type: Sandwich
• Detection Range: 31.25-2000pg/mL
• Sensitivity: 14.1pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 112421031
• NCBI GeneID: 19123
• NCBI Accession #: NP_001036232.1
• NCBI GenBank Nucleotide #: NM_001042767.3
• UniProt Accession #: P33587; O35498; Q91WN8; Q99PC6
• Molecular Weight: 51,818 Da
• NCBI Official Full Name: vitamin K-dependent protein C isoform 2 preproprotein
• NCBI Official Synonym Full Names: protein C
• NCBI Official Symbol: Proc
• NCBI Official Synonym Symbols: PC
• NCBI Protein Information: vitamin K-dependent protein C
• UniProt Protein Name: Vitamin K-dependent protein C
• Protein Family: Vitamin K-dependent protein
• UniProt Gene Name: Proc

NCBI Description

This gene encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The encoded protein undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease that degrades activated coagulation factors. A complete lack of the encoded protein in mice results in severe perinatal consumptive coagulopathy in the brain and liver, resulting in death within 24 hours after birth. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]

Uniprot Description

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.