Mouse Prion Protein (PRNP) ELISA Kit | PRNP elisa kit

Mouse Prion Protein (PRNP) ELISA Kit

Cat. Num. AAA452955

• Gene Names: Prnp; PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP<C>; AA960666; AI325101; prP27-30; prP33-35C
• Reactivity: Mouse
• Synonyms: Prion Protein (PRNP); Mouse Prion Protein (PRNP) ELISA Kit; CD230; GSS; ASCR; CJD; PRIP; PrP; PrP2730; PrPc; Major prion protein; Creutzfeldt-Jakob Disease; Gerstmann-Strausler-Scheinker Syndrome; Fatal Familial Insomnia; PRNP elisa kit

• Reactivity: Mouse
• Sequence Length: 254

• Samples: Tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.061ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 506326231
• NCBI GeneID: 19122
• NCBI Accession #: NP_001265185.1
• NCBI GenBank Nucleotide #: NM_001278256.1
• UniProt Accession #: P04925
• Molecular Weight: 27,977 Da
• NCBI Official Full Name: major prion protein
• NCBI Official Synonym Full Names: prion protein
• NCBI Official Symbol: Prnp
• NCBI Official Synonym Symbols: PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP<C>; AA960666; AI325101; prP27-30; prP33-35C
• NCBI Protein Information: major prion protein
• UniProt Protein Name: Major prion protein
• Protein Family: Major prion protein
• UniProt Gene Name: Prnp
• UniProt Synonym Gene Names: Prn-p; Prp; PrP

Uniprot Description

Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (PubMed:12732622, PubMed:16492732, PubMed:19242475, PubMed:19568430).