Mouse Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN ELISA Kit | Pten elisa kit

Mouse Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN ELISA Kit

Cat. Num. AAA2882438

• Gene Names: Pten; TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik
• Reactivity: Mouse
• Synonyms: Phosphatidylinositol-3; 4; 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mouse Phosphatidylinositol-3; 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN ELISA Kit; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; Pten; Mmac1; Pten elisa kit

• Reactivity: Mouse
• Sequence Length: 403

• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 6679523
• NCBI GeneID: 19211
• NCBI Accession #: NP_032986.1
• NCBI GenBank Nucleotide #: NM_008960.2
• UniProt Accession #: O08586; Q3UFB0; Q542G1
• Molecular Weight: 47,152 Da
• NCBI Official Full Name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
• NCBI Official Synonym Full Names: phosphatase and tensin homolog
• NCBI Official Symbol: Pten
• NCBI Official Synonym Symbols: TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik
• NCBI Protein Information: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
• UniProt Protein Name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
• Protein Family: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase
• UniProt Gene Name: Pten
• UniProt Synonym Gene Names: Mmac1
• UniProt Entry Name: PTEN_MOUSE

NCBI Description

This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]

Uniprot Description

PTEN: a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability.

Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; Motility/polarity/chemotaxis; Phosphatase, lipid; Tumor suppressor; EC 3.1.3.48; Nuclear receptor co-regulator; EC 3.1.3.67

Cellular Component: apical plasma membrane; cell projection; cytoplasm; dendritic spine; internal side of plasma membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; plasma membrane; postsynaptic membrane

Molecular Function: enzyme binding; hydrolase activity; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; magnesium ion binding; PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; platelet-derived growth factor receptor binding; protein binding; protein kinase binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity

Biological Process: adult behavior; anaphase-promoting complex activation during mitotic cell cycle; angiogenesis; apoptosis; brain morphogenesis; cardiac muscle development; cell migration; central nervous system development; central nervous system neuron axonogenesis; dentate gyrus development; dephosphorylation; endothelial cell migration; forebrain morphogenesis; G1/S-specific negative regulation of cyclin-dependent protein kinase activity; heart development; inositol phosphate dephosphorylation; learning and/or memory; lipid metabolic process; locomotor rhythm; locomotory behavior; male mating behavior; maternal behavior; memory; multicellular organismal response to stress; myelin maintenance in the central nervous system; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of epithelial cell proliferation; negative regulation of focal adhesion formation; negative regulation of myelination; negative regulation of organ growth; negative regulation of phagocytosis; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase B signaling cascade; nerve-nerve synaptic transmission; nervous system development; neurite development; phosphoinositide dephosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of transcription factor activity; prepulse inhibition; protein amino acid dephosphorylation; protein kinase B signaling cascade; protein stabilization; regulation of axon regeneration; regulation of B cell apoptosis; regulation of cell cycle; regulation of cellular component size; regulation of myeloid cell apoptosis; regulation of protein stability; regulation of synaptic transmission, GABAergic; rhythmic synaptic transmission; social behavior; synapse maturation; synaptogenesis; Wnt receptor signaling pathway through beta-catenin