Mouse NKX3-1/Homeobox Protein Nkx-3.1 ELISA Kit | NKX3-1 elisa kit
Mouse NKX3-1/Homeobox Protein Nkx-3.1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NKX3-1: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Interacts with serum response factor (SRF). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation. By androgens and, in the LNCAP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen- independent phase. Highly expressed in the prostate and, at a lower level, in the testis. Belongs to the NK-3 homeobox family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Tumor suppressor; DNA-binding
Cellular Component: intracellular; nucleus
Molecular Function: protein binding; androgen receptor activity; estrogen receptor activity; DNA binding; protein self-association; sequence-specific DNA binding; histone deacetylase binding; estrogen receptor binding; caspase activator activity; protein kinase activator activity; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; prostate gland development; salivary gland development; positive regulation of transcription, DNA-dependent; multicellular organismal development; negative regulation of insulin-like growth factor receptor signaling pathway; positive regulation of caspase activity; positive regulation of mitotic cell cycle; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; protein kinase B signaling cascade; negative regulation of mitotic cell cycle; negative regulation of epithelial cell proliferation; caspase activation; transcription, DNA-dependent; response to testosterone stimulus; positive regulation of phosphoinositide 3-kinase cascade; internal genitalia morphogenesis; branching morphogenesis of a tube; positive regulation of protein kinase activity; positive regulation of cell division; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; urogenital system development
Research Articles on NKX3-1
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Product Notes
The Mouse NKX3-1 nkx3-1 (Catalog #AAA2890070) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2890070 ELISA Kit recognizes Mouse NKX3-1. It is sometimes possible for the material contained within the vial of "NKX3-1/Homeobox Protein Nkx-3.1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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