Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Neurabin-2 (PPP1R9B) Standard Curve.)
Mouse Neurabin-2 (PPP1R9B) ELISA Kit | PPP1R9B elisa kit
Mouse Neurabin-2 (PPP1R9B) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Neurabin-2 (PPP1R9B) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Neurabin-2 (PPP1R9B) Standard Curve.)
Background: Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system.To identify proteins that interact with the ARF protein encoded by the CDKN2A gene, Vivo et al. (2001) used a yeast 2-hybrid screen of a human brain cDNA library with an ARF fusion construct as bait. By database searching with the identified clones, they reconstructed a full-length cDNA of human spinophilin. The deduced 813-amino acid protein shares 95% sequence identity with the rat homolog and contains an F-actin binding domain, a PP1C binding site, a PDZ domain, and a myosin-like left-handed alpha helix.
NCBI and Uniprot Product Information
Uniprot Description
Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain.
Protein type: Protein phosphatase, regulatory subunit; Adaptor/scaffold
Cellular Component: actin cytoskeleton; cell junction; cell projection; cell soma; cortical actin cytoskeleton; cytoplasm; cytoskeleton; dendrite; dendritic spine; filopodium; growth cone; lamellipodium; membrane; neuron projection; nucleoplasm; nucleus; plasma membrane; postsynaptic density; synapse
Molecular Function: actin binding; actin filament binding; D2 dopamine receptor binding; kinase binding; protein binding; protein C-terminus binding; protein complex binding; protein kinase activity; protein phosphatase 1 binding; protein phosphatase inhibitor activity
Biological Process: actin cytoskeleton organization and biogenesis; actin filament organization; calcium-mediated signaling; cell differentiation; cell migration; dendrite development; filopodium formation; multicellular organismal development; negative regulation of cell growth; negative regulation of phosphoprotein phosphatase activity; nervous system development; protein amino acid phosphorylation; regulation of cell proliferation; regulation of protein amino acid phosphorylation; regulation of synaptic transmission
Research Articles on PPP1R9B
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Product Notes
The Mouse PPP1R9B ppp1r9b (Catalog #AAA9717307) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9717307 ELISA Kit recognizes Mouse PPP1R9B. It is sometimes possible for the material contained within the vial of "Neurabin-2 (PPP1R9B), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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