Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Mesoderm posterior protein 2 (MESP2) Standard Curve.)
Mouse Mesoderm Posterior Protein 2 (MESP2) ELISA Kit | MESP2 elisa kit
Mouse Mesoderm Posterior Protein 2 (MESP2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Mesoderm posterior protein 2 (MESP2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Mesoderm posterior protein 2 (MESP2) Standard Curve.)
Background: MESP2 encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. MESP2 is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. MESP2 also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
NCBI and Uniprot Product Information
Uniprot Description
MESP2: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defects in MESP2 are the cause of spondylocostal dysostosis type 2 (SCDO2). An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
Protein type: Transcription factor; Cell development/differentiation
Cellular Component: nucleus
Molecular Function: protein dimerization activity; DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; somitogenesis; Notch signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; mesodermal cell migration; somite rostral/caudal axis specification
Research Articles on MESP2
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Product Notes
The Mouse MESP2 mesp2 (Catalog #AAA9717660) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9717660 ELISA Kit recognizes Mouse MESP2. It is sometimes possible for the material contained within the vial of "Mesoderm Posterior Protein 2 (MESP2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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