Murine: IL-12p40, IL-12p80
The antigens listed below were tested at 50 ng/ml and exhibited less than 1% cross reactivity.
Human: IL-12p40, IL-12p70, IL-12p80
The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.
Human: IFN-gamma, IL-10
Murine: IFN-gamma, IL-10
NCBI and Uniprot Product Information
Uniprot Description
IL12A: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-6 superfamily.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3 E1|3 31.92 cM
Cellular Component: cytoplasm; extracellular region; extracellular space; interleukin-12 complex
Molecular Function: cytokine activity; growth factor activity; interleukin-12 beta subunit binding; interleukin-12 receptor binding; interleukin-27 binding; protein heterodimerization activity
Biological Process: cell cycle arrest; cell migration; cell proliferation; defense response to protozoan; immune response; interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of smooth muscle cell proliferation; positive regulation of cell adhesion; positive regulation of interferon-gamma production; positive regulation of lymphocyte proliferation; positive regulation of mononuclear cell proliferation; positive regulation of natural killer cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of NK T cell activation; positive regulation of T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; response to lipopolysaccharide; response to UV-B
Research Articles on IL-12
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Product Notes
The Mouse IL-12 il12a (Catalog #AAA9501905) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501905 ELISA Kit recognizes Mouse IL-12. It is sometimes possible for the material contained within the vial of "IL-12, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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