Mouse Hepatocyte Growth Factor (HGF) ELISA Kit | HGF elisa kit

Mouse Hepatocyte Growth Factor (HGF) ELISA Kit

Cat. Num. AAA3805410

• Gene Names: Hgf; SF; NK1; NK2; HGF/SF; SF/HGF; C230052L06Rik
• Reactivity: Mouse
• Synonyms: Hepatocyte Growth Factor (HGF); Mouse Hepatocyte Growth Factor (HGF) ELISA Kit; HGF elisa kit

• Reactivity: Mouse
• Sequence Length: 728

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 50 pg/ml-800 pg/ml
• Sensitivity: 1 pg/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for HGF elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofHGFin the sample, This HGFELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusHGFconcentration. The concentration ofHGFin the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 575501559
• NCBI GeneID: 15234
• NCBI Accession #: NP_001276387.1
• NCBI GenBank Nucleotide #: NP_001276387.1
• UniProt Accession #: Q08048
• NCBI Official Full Name: hepatocyte growth factor isoform 1 preproprotein
• NCBI Official Synonym Full Names: hepatocyte growth factor
• NCBI Official Symbol: Hgf
• NCBI Official Synonym Symbols: SF; NK1; NK2; HGF/SF; SF/HGF; C230052L06Rik
• NCBI Protein Information: hepatocyte growth factor
• UniProt Protein Name: Hepatocyte growth factor
• Protein Family: Hepatocyte growth factor
• UniProt Gene Name: Hgf
• UniProt Synonym Gene Names: SF
• UniProt Entry Name: HGF_MOUSE

NCBI Description

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Uniprot Description

HGF: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization. Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39). A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the peptidase S1 family. Plasminogen subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Hormone; Cell development/differentiation; Motility/polarity/chemotaxis

Cellular Component: extracellular space; membrane

Molecular Function: chemoattractant activity; growth factor activity; identical protein binding; protein heterodimerization activity; serine-type endopeptidase activity

Biological Process: activation of MAPK activity; cell morphogenesis; cell proliferation; hepatocyte growth factor receptor signaling pathway; liver development; myoblast proliferation; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of inflammatory response; negative regulation of interleukin-6 production; negative regulation of peptidyl-serine phosphorylation; positive chemotaxis; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of interleukin-10 production; positive regulation of myelination; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; proteolysis