Mouse E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) ELISA Kit | NEDD4L elisa kit
Mouse E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NEDD4L: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Interacts with UBE2E3. Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase. Interacts via its WW domains with SCNN1A, SCNN1B, SCNN1G, SCN1A, SCN2A, SCN3A, SCN5A, SCN8A, SCN9A, SCN10A and CLCN5. Interacts with SMAD2, SMAD3, SMAD6 and SMAD7. The phosphorylated form interacts with 14-3-3 proteins. Interacts with Epstein-Barr virus LMP2A. Interacts with TNK2. Interacts with WNK1. Interacts with SGK1. By androgens in prostate, and by albumin in kidney. Ubiquitously expressed, with highest levels in prostate, pancreas and kidney. Activated by NDFIP1- and NDFIP2-binding. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Ligase
Cellular Component: cytoplasm; plasma membrane; nucleus
Molecular Function: sodium channel inhibitor activity; protein binding; potassium channel regulator activity; sodium channel regulator activity; coenzyme F420-2 alpha-glutamyl ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; ubiquitin-protein ligase activity; ribosomal S6-glutamic acid ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; potassium channel inhibitor activity; ligase activity
Biological Process: protein monoubiquitination; response to metal ion; proteasomal ubiquitin-dependent protein catabolic process; regulation of membrane potential; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; negative regulation of systemic arterial blood pressure; protein ubiquitination during ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; protein ubiquitination; response to salt stress
Research Articles on NEDD4L
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Product Notes
The Mouse NEDD4L nedd4l (Catalog #AAA9322441) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322441 ELISA Kit recognizes Mouse NEDD4L. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase NEDD4-like (NEDD4L), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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