Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Disks large homolog 2 (DLG2) Standard Curve.)
Mouse Disks Large Homolog 2 (DLG2) ELISA Kit | DLG2 elisa kit
Mouse Disks Large Homolog 2 (DLG2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Disks large homolog 2 (DLG2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Disks large homolog 2 (DLG2) Standard Curve.)
Background: Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.The dlg-A protein had been shown to act as a tumor suppressor, and the other members of this family may be involved in signal transduction through specialized membrane domains with highly organized cytoskeletons and thus are potential tumor suppressors.
NCBI and Uniprot Product Information
Uniprot Description
PSD-93: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; cell projection; membrane; cell soma; cytoplasm; dendrite; plasma membrane; ionotropic glutamate receptor complex; synapse; cell junction
Molecular Function: protein C-terminus binding; guanylate kinase activity; ionotropic glutamate receptor binding; protein binding; protein heterodimerization activity; protein phosphatase binding; kinase binding; PDZ domain binding
Biological Process: nervous system development; synaptic transmission; neuronal ion channel clustering; sensory perception of pain; receptor clustering; nucleotide phosphorylation
Research Articles on DLG2
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Product Notes
The Mouse DLG2 dlg2 (Catalog #AAA9717864) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9717864 ELISA Kit recognizes Mouse DLG2. It is sometimes possible for the material contained within the vial of "Disks Large Homolog 2 (DLG2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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