Mouse CYBB/Cytochrome b-245 Heavy Chain ELISA Kit | CYBB elisa kit
Mouse CYBB/Cytochrome b-245 Heavy Chain ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
Uniprot Description
CYBB: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of granulomatous disease,chronic, X-linked (CGD). A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life- threatening bacterial/fungal infections. Defects in CYBB are a cause of mycobacteriosis atypical X-linked type 2 (AMCBX2). A rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections.
Protein type: EC 1.-.-.-; Oxidoreductase; Mitochondrial; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: Golgi apparatus; mitochondrion; membrane; cell soma; rough endoplasmic reticulum; integral to plasma membrane; endoplasmic reticulum; cytoplasm; dendrite; integral to membrane; plasma membrane; intracellular; NADPH oxidase complex
Molecular Function: N-ethylmaleimide reductase activity; protein binding; FAD binding; electron carrier activity; protein heterodimerization activity; metal ion binding; superoxide-generating NADPH oxidase activity; malolactic enzyme activity; heme binding; voltage-gated ion channel activity; oxidoreductase activity; sulfur oxygenase reductase activity; F420H2 dehydrogenase activity
Biological Process: respiratory burst; response to drug; transport; superoxide metabolic process; innate immune response; ion transport; inflammatory response; superoxide release; hydrogen peroxide biosynthetic process
Research Articles on CYBB
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Product Notes
The Mouse CYBB cybb (Catalog #AAA2889779) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2889779 ELISA Kit recognizes Mouse CYBB. It is sometimes possible for the material contained within the vial of "CYBB/Cytochrome b-245 Heavy Chain, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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