Mouse Coagulation Factor VII (F7) ELISA Kit | F7 elisa kit
Mouse Coagulation Factor VII (F7) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a vitamin K-dependent serine protease that plays a critical role in the extrinsic pathway of blood coagulation. Upon contact with tissue factor III (TF III), the encoded protein forms an activated complex termed TF-FVIIa that initiates the coagulation cascade involving other coagulation factors, ultimately resulting in a fibrin clot. Complete lack of the encoded protein in mice results in in perinatal lethality due to bleeding from normal blood vessels. [provided by RefSeq, Apr 2015]
Uniprot Description
F7: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Defects in F7 are the cause of factor VII deficiency (FA7D). A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; EC 3.4.21.21; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8 A1.1|8 5.73 cM
Cellular Component: extracellular space; vesicle
Molecular Function: endopeptidase activity; glycoprotein binding; receptor binding; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process: blood coagulation; positive regulation of blood coagulation; positive regulation of leukocyte chemotaxis; positive regulation of positive chemotaxis; positive regulation of protein kinase B signaling cascade; protein processing; response to nutrient levels
Research Articles on F7
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Product Notes
The Mouse F7 f7 (Catalog #AAA2087914) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2087914 ELISA Kit recognizes Mouse F7. It is sometimes possible for the material contained within the vial of "Coagulation Factor VII (F7), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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