Mouse ATP-Binding Cassette Sub-Family D Member 2 (ABCD2) ELISA Kit | ABCD2 elisa kit

Mouse ATP-Binding Cassette Sub-Family D Member 2 (ABCD2) ELISA Kit

Cat. Num. AAA9362056

• Gene Names: ABCD2; ALDR; ABC39; ALDL1; ALDRP; hALDR
• Reactivity: Mouse
• Synonyms: ATP-Binding Cassette Sub-Family D Member 2 (ABCD2); Mouse ATP-Binding Cassette Sub-Family D Member 2 (ABCD2) ELISA Kit; ABCD2 elisa kit

• Reactivity: Mouse

• Assay Type: Quantitative Sandwich
• Detection Range: 0.625ng/ml-20ng/ml
• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for ABCD2 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of ABCD2 (hereafter termed "analyte") in undiluted original Mouse serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 9945308
• NCBI GeneID: 225
• NCBI Accession #: NP_005155.1
• NCBI GenBank Nucleotide #: NM_005164.3
• Molecular Weight: 83,233 Da
• NCBI Official Full Name: ATP-binding cassette sub-family D member 2
• NCBI Official Synonym Full Names: ATP binding cassette subfamily D member 2
• NCBI Official Symbol: ABCD2
• NCBI Official Synonym Symbols: ALDR; ABC39; ALDL1; ALDRP; hALDR
• NCBI Protein Information: ATP-binding cassette sub-family D member 2
• UniProt Protein Name: ATP-binding cassette sub-family D member 2
• Protein Family: ABC transporter D family
• UniProt Gene Name: ABCD2
• UniProt Synonym Gene Names: ALD1; ALDL1; ALDR; ALDRP; hALDR
• UniProt Entry Name: ABCD2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCD2: Probable transporter. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein type: Membrane protein, integral; Transporter, ABC family; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: cytosol; integral to membrane; intracellular membrane-bound organelle; peroxisomal membrane; peroxisome

Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; protein binding; protein homodimerization activity

Biological Process: fatty acid beta-oxidation; positive regulation of fatty acid beta-oxidation; transmembrane transport; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process