Mouse Interleukin 1 Receptor Accessory Protein (IL1RAP) CLIA Kit | IL1RAP clia kit

Mouse Interleukin 1 Receptor Accessory Protein (IL1RAP) CLIA Kit

Cat. Num. AAA2709190

• Gene Names: Il1rap; AI255955; AV239853; IL-1RAcP; 6430709H04Rik
• Reactivity: Mouse
• Applications: Chemiluminescence Immunoassay (CLIA)
• Synonyms: Interleukin 1 Receptor Accessory Protein (IL1RAP); Mouse Interleukin 1 Receptor Accessory Protein (IL1RAP) CLIA Kit; Interleukin 1 Receptor Accessory Protein; IL-1RAcP; C3orf13; IL1R3; Interleukin-1 receptor 3; IL1RAP clia kit

• Reactivity: Mouse
• Specificity: This assay has high sensitivity and excellent specificity for detection of Interleukin 1 Receptor Accessory Protein (IL1RAP).; No significant cross-reactivity or interference between Interleukin 1 Receptor Accessory Protein (IL1RAP) and analogues was observed.
• Sequence Length: 685

• Applicable Applications for IL1RAP clia kit: Chemiluminescence Immunoassay (CLIA)
• Assay Type: Double-antibody Sandwich
• Samples: Serum, plasma and other biological fluids
• Detection Range: 2.74-2,000pg/mL
• Sensitivity: The minimum detectable dose of this kit is typically less than 1.23pg/mL
• Precision: Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interleukin 1 Receptor Accessory Protein (IL1RAP) were tested 20 times on one plate, respectively.; Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Interleukin 1 Receptor Accessory Protein (IL1RAP) were tested on 3 different plates, 8 replicates in each plate.; CV(%) = SD/meanX100; Intra-Assay: CV<10%; Inter-Assay: CV<12%
• Test Principle: The microplate provided in this kit has been pre-coated with an antibody specific to Interleukin 1 Receptor Accessory Protein (IL1RAP). Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Interleukin 1 Receptor Accessory Protein (IL1RAP). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then the mixture of substrate A and B is added to generate glow light emission kinetics. Upon plate development, the intensity of the emitted light is proportional to the Interleukin 1 Receptor Accessory Protein (IL1RAP) level in the sample or standard.
• Preparation and Storage: The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.; To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

NCBI and Uniprot Product Information

• NCBI GI #: 226693333
• NCBI GeneID: 16180
• NCBI Accession #: NP_001152790.1
• NCBI GenBank Nucleotide #: NP_001152790.1
• UniProt Accession #: Q61730
• NCBI Official Full Name: interleukin-1 receptor accessory protein isoform d
• NCBI Official Synonym Full Names: interleukin 1 receptor accessory protein
• NCBI Official Symbol: Il1rap
• NCBI Official Synonym Symbols: AI255955; AV239853; IL-1RAcP; 6430709H04Rik
• NCBI Protein Information: interleukin-1 receptor accessory protein
• UniProt Protein Name: Interleukin-1 receptor accessory protein
• Protein Family: Interleukin-1 receptor accessory protein
• UniProt Gene Name: Il1rap
• UniProt Synonym Gene Names: IL-1 receptor accessory protein; IL-1RAcP

Uniprot Description

Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Coreceptor for IL1RL1 in the IL-33 signaling system.