Typical Testing Data/Standard Curve (for reference only)
Mouse DNM1 (Dynamin 1) CLIA Kit | DNM1 clia kit
Mouse DNM1 (Dynamin 1) CLIA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to DNM1. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for DNM1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain DNM1, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of DNM1. You can calculate the concentration of DNM1 in the samples by comparing the RLU value of the samples to the standard curve.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Description
DYN1: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain.
Protein type: Hydrolase; EC 3.6.5.5; Motor; Motility/polarity/chemotaxis; Vesicle; Microtubule-binding
Cellular Component: Golgi apparatus; microtubule; synaptic vesicle; cytoskeleton; photoreceptor inner segment; protein complex; membrane coat; cytoplasm; plasma membrane; synapse; myelin sheath
Molecular Function: protein C-terminus binding; GTPase activity; protein dimerization activity; identical protein binding; protein binding; GTP binding; hydrolase activity; nucleotide binding; protein complex binding; nitric-oxide synthase binding; protein kinase binding; D2 dopamine receptor binding
Biological Process: receptor-mediated endocytosis; sensory perception of sound; endosome organization and biogenesis; G-protein coupled receptor internalization; adult locomotory behavior; receptor internalization; synaptic transmission, GABAergic; endocytosis; protein tetramerization
Research Articles on DNM1
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Product Notes
The Mouse DNM1 dnm1 (Catalog #AAA2532323) is a CLIA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2532323 CLIA Kit recognizes Mouse DNM1. It is sometimes possible for the material contained within the vial of "DNM1 (Dynamin 1), CLIA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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