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Western Blot (WB) (Western blot analysis using WDR5 mouse mAb against Hela (1) cell lysate.)

Mouse anti-Human WDR5 Monoclonal Antibody | anti-WDR5 antibody

Anti-WDR5 Mouse mAb

Gene Names
WDR5; SWD3; BIG-3; CFAP89
Reactivity
Human
Applications
Western Blot
Synonyms
WDR5; Monoclonal Antibody; Anti-WDR5 Mouse mAb; SWD3; BIG-3; anti-WDR5 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
7B11
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Sequence Length
334
Applicable Applications for anti-WDR5 antibody
Western Blot (WB)
Immunogen
Purified recombinant fragment of human WDR5 expressed in E Coli.

Western Blot (WB)

(Western blot analysis using WDR5 mouse mAb against Hela (1) cell lysate.)

Western Blot (WB) (Western blot analysis using WDR5 mouse mAb against Hela (1) cell lysate.)
Related Product Information for anti-WDR5 antibody
Entrez Summary: WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
36.6
NCBI Official Full Name
WD repeat-containing protein 5
NCBI Official Synonym Full Names
WD repeat domain 5
NCBI Official Symbol
WDR5
NCBI Official Synonym Symbols
SWD3; BIG-3; CFAP89
NCBI Protein Information
WD repeat-containing protein 5
UniProt Protein Name
WD repeat-containing protein 5
UniProt Gene Name
WDR5
UniProt Synonym Gene Names
BIG3

NCBI Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

WDR5: a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34.2

Cellular Component: histone acetyltransferase complex; histone methyltransferase complex; nucleoplasm; nucleus

Molecular Function: histone acetyltransferase activity (H4-K16 specific); histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; methylated histone residue binding; protein binding

Biological Process: histone H3-K4 methylation

Research Articles on WDR5

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Product Notes

The WDR5 wdr5 (Catalog #AAA476043) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-WDR5 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's WDR5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the WDR5 wdr5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WDR5, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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