Immunohistochemistry (IHC)
(Anti-VTN/Vitronectin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Mouse VTN/Vitronectin Monoclonal Antibody | anti-VTN antibody
Anti-VTN/Vitronectin Antibody (aa1-310, clone 6F212)
Gene Names
VTN; VN; V75; VNT
Reactivity
HumanPredicted: Rabbit, Dog, Bovine, Cat
Applications
ELISA, Immunohistochemistry, Western Blot
Purity
Protein A/G purified
Synonyms
VTN/Vitronectin; Monoclonal Antibody; Anti-VTN/Vitronectin Antibody (aa1-310; clone 6F212); Mouse Monoclonal (IgG1) to Human VTN/Vitronectin; VTN; Epibolin; Serum-spreading factor; VNT; S-protein; Somatomedin B; V75; VN; Complement S-protein; Serum spreading factor; Vitronectin; anti-VTN antibody
Host
Mouse
Reactivity
Human
Predicted: Rabbit, Dog, Bovine, Cat
Predicted: Rabbit, Dog, Bovine, Cat
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
6F212
Specificity
Highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). Cross-reacts with vitronectin from cat, dog, rabbit and to a lesser extent with cow. Epitope is located within a cyanogen bromide cleavage fragment comprising aa 1-310. Binds nearly as well to native vitronectin as to denatured. It interferes with vitronectin-inhibition of the lysis of terminal complement complexes (TCC) and it inhibits vitronectin binding of PAI-1.
Purity/Purification
Protein A/G purified
Form/Format
PBS, pH 7.4, 15 mM sodium azide
Sequence Length
478
Applicable Applications for anti-VTN antibody
ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes
ELISA: 1:40000
IHC-P: 10 ug/ml
WB: 1:50
IHC-P: 10 ug/ml
WB: 1:50
Immunogen
Human vitronectin purified from plasma by heparin-affinity chromatography.
Conjugation
Unconjugated
Epitope
aa1-310
Preparation and Storage
Short term: 4 degree C
Long term: -20 degree C.
Avoid freeze-thaw cycles.
Long term: -20 degree C.
Avoid freeze-thaw cycles.
Immunohistochemistry (IHC)
(Anti-VTN/Vitronectin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-VTN/Vitronectin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (WB)
(Anti-VTN/Vitronectin antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Immunohistochemistry (WB)
(Anti-VTN/Vitronectin antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Related Product Information for anti-VTN antibody
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans.Is recognized by certain members of the integrin family and serves as acell-to-substrate adhesion molecule. Inhibitor of the membrane-damagingeffect of the terminal cytolytic complement pathway.Somatomedin-B is agrowth hormone-dependent serum factor with protease-inhibiting activity.
Product Categories/Family for anti-VTN antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
54,306 Da
NCBI Official Full Name
vitronectin
NCBI Official Synonym Full Names
vitronectin
NCBI Official Symbol
VTN
NCBI Official Synonym Symbols
VN; V75; VNT
NCBI Protein Information
vitronectin
UniProt Protein Name
Vitronectin
Protein Family
UniProt Gene Name
VTN
UniProt Synonym Gene Names
VN
NCBI Description
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
Uniprot Description
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Research Articles on VTN
Similar Products
Product Notes
The VTN vtn (Catalog #AAA2400942) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-VTN/Vitronectin Antibody (aa1-310, clone 6F212) reacts with Human Predicted: Rabbit, Dog, Bovine, Cat and may cross-react with other species as described in the data sheet. AAA Biotech's VTN/Vitronectin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB). ELISA: 1:40000 IHC-P: 10 ug/ml WB: 1:50. Researchers should empirically determine the suitability of the VTN vtn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VTN/Vitronectin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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