Mouse anti-Human VDR Monoclonal Antibody | anti-VDR antibody

VDR (Vitamin D3 Receptor, 1,25-dihydroxyvitamin D3 Receptor, Nuclear Receptor Subfamily 1 Group I Member 1, NR1I1) APC

Cat. Num. AAA6139830

• Gene Names: VDR; NR1I1; PPP1R163
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: VDR; Monoclonal Antibody; VDR (Vitamin D3 Receptor; 1; 25-dihydroxyvitamin D3 Receptor; Nuclear Receptor Subfamily 1 Group I Member 1; NR1I1) APC; Vitamin D (1; 25- dihydroxyvitamin D3) Receptor; anti-VDR antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a,k
• Clone Number: 2F4
• Specificity: Recognizes human VDR.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-VDR antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 3ug/ml; Applications are based on unconjugated antibody.
• Immunogen: Full length recombinant corresponding to aa1-427 from human VDR (AAH60832) with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
• Conjugate: APC
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Testing Data

(Immunoperoxidase of monoclonal antibody to VDR on formalin-fixed paraffin-embedded human lung. [antibody concentration 3ug/ml])

Testing Data

(Detection limit for recombinant GST tagged VDR is ~1ng/ml as a capture antibody.)

Product Categories/Family for anti-VDR antibody

Antibodies; Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 38511971
• NCBI GeneID: 7421
• Molecular Weight: 53,883 Da
• NCBI Official Full Name: Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor, mRNA
• NCBI Official Synonym Full Names: vitamin D (1,25- dihydroxyvitamin D3) receptor
• NCBI Official Symbol: VDR
• NCBI Official Synonym Symbols: NR1I1; PPP1R163
• NCBI Protein Information: vitamin D3 receptor
• Protein Family: Vitamin D3 receptor

NCBI Description

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]