Immunofluorescence (IF)
(Immunofluorescent staining of COS7 cells transiently transfected with recombinant UBA2 protein using UBA2 antibody)
Mouse UBA2 Monoclonal Antibody | anti-UBA2 antibody
UBA2 antibody
IHC: 1:150
WB: 1:500-2000
Immunofluorescence (IF)
(Immunofluorescent staining of COS7 cells transiently transfected with recombinant UBA2 protein using UBA2 antibody)
Immunofluorescence (IF)
(Immunofluorescent staining of COS7 cells transiently transfected with recombinant UBA2 protein using UBA2 antibody)
Western Blot (WB)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant UBA2 protein (Right) or empty vector (Left) detected with UBA2 antibody)
Western Blot (WB)
(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant UBA2 protein (Right) or empty vector (Left) detected with UBA2 antibody)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of UBA2 protein in paraffin embedded Human prostate tissue using UBA2 antibody)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of UBA2 protein in paraffin embedded Human prostate tissue using UBA2 antibody)
NCBI and Uniprot Product Information
NCBI Description
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Uniprot Description
SAE2: a protein of the ubiquitin-activating E1 family. Acts as a UBL1 E1 ligase. Mediates ATP-dependent activation of UBL1 and formation of a thiolester with a conserved cysteine residue on SAE2.
Protein type: Ligase; Ubiquitin conjugating system; Motility/polarity/chemotaxis; EC 6.3.2.19; Ubiquitin ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 19q12
Cellular Component: nucleoplasm; cytosol; nucleus
Molecular Function: SUMO activating enzyme activity; protein binding; protein heterodimerization activity; metal ion binding; enzyme activator activity; transcription factor binding; ATP binding
Biological Process: positive regulation of catalytic activity; protein sumoylation; cellular protein metabolic process; SMT3-dependent protein catabolic process; post-translational protein modification
Research Articles on UBA2
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Product Notes
The UBA2 uba2 (Catalog #AAA834233) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's UBA2 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). IF: 1:100 IHC: 1:150 WB: 1:500-2000. Researchers should empirically determine the suitability of the UBA2 uba2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UBA2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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