Mouse anti-Human Transforming Growth Factor beta Receptor III Monoclonal Antibody | anti-TGFBR3 antibody
Transforming Growth Factor beta Receptor III (TGF beta Receptor III, TGF beta RIII, TGFR-3, Betaglycan)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: Western Blot: This antibody can be used at 1-2ug/mL with the appropriate secondary reagents to detect human TGF- RIII. The detection limit for rhTGF- RIII is approximately 50 ng/lane under non-reducing conditions.
Direct ELISA: This antibody can be used at 0.5-1.0ug/mL with the appropriate secondary reagents to detect human TGF- RIII. The detection limit for rhTGF- RIII is approximately 15 ng/well.
NCBI and Uniprot Product Information
NCBI Description
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Uniprot Description
TGFBR3: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p33-p32
Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum; integral to plasma membrane; receptor complex; external side of plasma membrane
Molecular Function: heparin binding; transforming growth factor beta receptor activity; protein binding; fibroblast growth factor binding; glycosaminoglycan binding; transforming growth factor beta binding; punt binding; activin binding; coreceptor activity; SMAD binding; transforming growth factor beta receptor binding; PDZ domain binding
Biological Process: transforming growth factor beta receptor complex assembly; heart morphogenesis; blood vessel development; blastocyst development; cell migration; organ regeneration; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of cell motility; cardiac muscle cell proliferation; palate development; liver development; activation of NF-kappaB transcription factor; BMP signaling pathway; regulation of protein binding; transforming growth factor beta receptor signaling pathway; response to hypoxia; epithelial to mesenchymal transition; ventricular cardiac muscle morphogenesis; immune response; cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; response to follicle-stimulating hormone stimulus; negative regulation of epithelial cell proliferation
Research Articles on TGFBR3
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Product Notes
The TGFBR3 tgfbr3 (Catalog #AAA603189) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Transforming Growth Factor beta Receptor III (TGF beta Receptor III, TGF beta RIII, TGFR-3, Betaglycan) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Transforming Growth Factor beta Receptor III can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Western Blot, Direct ELISA Dilution: Western Blot: This antibody can be used at 1-2ug/mL with the appropriate secondary reagents to detect human TGF- RIII. The detection limit for rhTGF- RIII is approximately 50 ng/lane under non-reducing conditions. Direct ELISA: This antibody can be used at 0.5-1.0ug/mL with the appropriate secondary reagents to detect human TGF- RIII. The detection limit for rhTGF- RIII is approximately 15 ng/well. Researchers should empirically determine the suitability of the TGFBR3 tgfbr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Transforming Growth Factor beta Receptor III, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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