Mouse anti-Human TRAIL Monoclonal Antibody
Mouse Anti-Human TRAIL-UNLB
Reactivity
Human
Applications
ELISA
Synonyms
TRAIL; Monoclonal Antibody; Mouse Anti-Human TRAIL-UNLB; Mouse anti-Human TRAIL; anti-TRAIL antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
SB91a
Specificity
Reacts with Human TRAIL
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells2,3. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of Caspase-84,5.
Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines6. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells2,3. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of Caspase-84,5.
Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines6. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
Form/Format
Purified (UNLB) Antibody
Applicable Applications for anti-TRAIL antibody
ELISA
Application Notes
ELISA: 0.1 - 1.0ug/mL
Immunogen
Full Length Recombinant Human TRAIL
Characterization
To ensure acceptable performance, each batch of product is tested by ELISA to conform to characteristics of a standard reference reagent.
Preparation and Storage
The purified (UNLB) antibody is supplied as 0.5mg purified immunoglobulin in 1.0mL of 100mM borate buffered saline, pH 8.0; store at 2-8 degree C.
Reagents are stable for the period shown on the label if stored as directed.
Reagents are stable for the period shown on the label if stored as directed.
References
1) Zamai, L. et al. (1998). J. Exp. Med. 188:2375-80.
3) Jin, Z. and El-Deiry, W.S. (2006). Mol. Cell. Biol. 26:8136-48.
4) Thorburn, A. (2004). Cell. Sign. 16:139-44.
5) Micheau, O. and Tschopp, J. (2003). Cell. 114:181-90.
6) Nagane, M. et al. (2001). Apop. 6:191-7.
3) Jin, Z. and El-Deiry, W.S. (2006). Mol. Cell. Biol. 26:8136-48.
4) Thorburn, A. (2004). Cell. Sign. 16:139-44.
5) Micheau, O. and Tschopp, J. (2003). Cell. 114:181-90.
6) Nagane, M. et al. (2001). Apop. 6:191-7.
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Product Notes
The TRAIL (Catalog #AAA670328) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human TRAIL-UNLB reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRAIL can be used in a range of immunoassay formats including, but not limited to, ELISA. ELISA: 0.1 - 1.0ug/mL. Researchers should empirically determine the suitability of the TRAIL for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRAIL, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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